Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Folates and the fetus

T K Eskes1

  • 1Institute for the Prevention of Birth Defects, University Hospital Nijmegen Sint Radboud, Netherlands. G.Theunissen@obgyn.azn.nl

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stereospecific in vitro embryotoxicity of l-homocysteine in pre- and post-implantation rodent embryos.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

Homocysteine metabolism and effects of folic acid supplementation in patients affected with spina bifida.

Neuropediatrics·2001
Same author

Clotting disorders and placental abruption: homocysteine--a new risk factor.

European journal of obstetrics, gynecology, and reproductive biology·2001
Same author

Homocysteine and human reproduction.

Clinical and experimental obstetrics & gynecology·2001
Same author

[Link between prenatal exposure to the 'Winter of Famine' and long-term medical consequences].

Nederlands tijdschrift voor geneeskunde·2001
Same author

Homocysteine-lowering effect of 500 microg folic acid every other day versus 250 microg/day.

Annals of nutrition & metabolism·2001
Same journal

Comparing effectiveness of sacrospinous hysteropexy to vaginal hysterectomy with sacrospinous ligament fixation.

European journal of obstetrics, gynecology, and reproductive biology·2026
Same journal

Rehabilitation strategies in post menopausal women: a systematic review and meta-analysis of randomized trials.

European journal of obstetrics, gynecology, and reproductive biology·2026
Same journal

Updated structured report for dynamic ultrasonography in patients with suspected or known endometriosis: Recommendations of the international society for gynecologic endoscopy (ISGE).

European journal of obstetrics, gynecology, and reproductive biology·2026
Same journal

Clinicopathologic prognostic factors and the role of adenomyosis in endometrial cancer: A 25-year single-center experience.

European journal of obstetrics, gynecology, and reproductive biology·2026
Same journal

Mid-pregnancy cervical length and pregnancy outcomes in nulliparous and low-risk multiparous singleton pregnancies: A prospective cohort study (the Quadruple P Screening Study).

European journal of obstetrics, gynecology, and reproductive biology·2026
Same journal

Major postpartum haemorrhage in nulliparous women stratified by induction and augmentation of labour and mode of birth from 2000 -2024: a population-based cohort study in the Netherlands.

European journal of obstetrics, gynecology, and reproductive biology·2026
See all related articles

Folic acid supplementation before conception significantly reduces neural tube defects (NTDs) by addressing hyperhomocysteinemia and MTHFR gene mutations. This intervention helps overcome genetic metabolic defects linked to NTDs.

Area of Science:

  • Obstetrics and Gynecology
  • Medical Genetics
  • Nutritional Science

Background:

  • Neural tube defects (NTDs) are a significant concern in congenital abnormalities.
  • Periconceptional folic acid intake is a known preventive measure for NTDs.

Purpose of the Study:

  • To investigate the role of hyperhomocysteinemia and methylenetetrahydrofolate-reductase (MTHFR) gene mutations in folic acid-preventable NTDs.
  • To explore the folate methylation cycle's involvement in NTD etiology.

Main Methods:

  • Analysis of genetic predisposition (MTHFR gene mutations).
  • Assessment of hyperhomocysteinemia as a contributing factor.
  • Hypothesizing the role of the folate methylation cycle.

Main Results:

Related Experiment Videos

  • Folic acid-preventable NTDs are associated with hyperhomocysteinemia.
  • A genetic predisposition, specifically MTHFR gene mutations, contributes to NTDs.
  • Reduced folate methylation cycle activity is a plausible etiological factor.

Conclusions:

  • Periconceptional folic acid and vitamin B12 can correct the genetic metabolic defect causing NTDs.
  • Understanding the folate methylation cycle provides insights into NTD prevention strategies.