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[Combination of the sieve effect and ion exchange chromatography during isolation of recombinant alpha2-interferon on
Prikladnaia Biokhimiia I Mikrobiologiia
|January 1, 1997
Abstract:
Preliminary purification of alpha 2-interferon from the culture liquid on cation-exchange sorbents was studied. Application of a cellosorbent based on the cationite KU-23 resulted in a 20-25-fold purification of recombinant alpha 2-interferon in a one-step process as a result of combination of the sieve effect and ion-exchange chromatography.