Low-density lipoprotein adsorption for arteriosclerotic patients

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Published on: November 10, 2017

Y Sato1, T Agishi

  • 1Kidney Center, Tokyo Women's Medical College, Japan.

Artificial Organs
|April 1, 1996
PubMed

Insights

Low-density lipoprotein (LDL) apheresis effectively treats arteriosclerosis obliterans (ASO) by lowering lipid levels, improving circulation, and alleviating symptoms like intermittent claudication in patients with hyperlipidemia.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Surgery
  • Lipidology

Background:

  • Arteriosclerosis obliterans (ASO) presents treatment challenges, particularly in drug-resistant hyperlipidemia.
  • Existing therapies for ASO are not always successful, necessitating alternative approaches.

Purpose of the Study:

  • To evaluate the efficacy of low-density lipoprotein (LDL) apheresis in managing lipid levels and clinical outcomes in ASO patients.
  • To assess the impact of LDL apheresis on intermittent claudication, lower extremity circulation, and blood rheology.

Main Methods:

  • LDL apheresis was performed using extracorporeal adsorption columns with dextran sulfate cellulose beads.
  • Clinical symptoms, physiological findings (plethysmogram, thermogram), and blood viscosity were monitored.
  • A follow-up questionnaire assessed long-term symptom maintenance after treatment cessation.

Main Results:

  • Over 80% of ASO patients experienced improved intermittent claudication and enhanced lower extremity circulation.
  • LDL apheresis significantly reduced blood viscosity, indicating improved blood rheology.
  • Long-term follow-up confirmed sustained clinical symptom improvement after treatment discontinuation.

Conclusions:

  • LDL apheresis is a valuable therapeutic option for ASO patients with elevated lipid levels and hyperlipidemia.
  • The procedure demonstrates sustained efficacy in improving vascular function and patient-reported outcomes.

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