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Aging, exercise, training, and the immune system

S Shinkai1, M Konishi, R J Shephard

  • 1Department of Public Health, Ehime University School of Medicine, Japan.

Exercise Immunology Review
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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Aging impairs immune function, particularly T cells and B cells. Regular exercise may improve natural killer (NK) cell activity and T cell function in older adults, potentially mitigating age-related immune decline.

Area of Science:

  • Immunology
  • Gerontology
  • Exercise Physiology

Background:

  • Human immune function declines with age, leading to immune deficiency and dysregulation.
  • Age-related changes significantly impact T cell distribution and function, as well as B cell antibody production.
  • Physical activity is known to modulate immune parameters.

Purpose of the Study:

  • To investigate the effects of acute and habitual exercise on immune function in aging.
  • To examine how exercise influences T cell, B cell, and natural killer (NK) cell activity in the elderly.

Main Methods:

  • Review of existing literature on exercise and immune function in aging.
  • Analysis of cross-sectional studies comparing immune status in physically active versus inactive older adults.

Related Experiment Videos

  • Assessment of NK cell activity following acute moderate exercise in elderly subjects.

    • Main Results:

    • Acute moderate exercise is well-tolerated by the elderly and may increase resting NK cell activity.
    • Habitual physical activity appears to enhance NK cell activity.
    • Regular exercise may counteract some age-related declines in T cell function.

    Conclusions:

    • Exercise, both acute and habitual, shows potential for improving immune function in older adults.
    • Further research is needed to determine if exercise-induced immune improvements translate to reduced risk of infections, malignancies, and autoimmune diseases.