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The integration host factor-DNA complex upstream of the early promoter of bacteriophage Mu is functionally symmetric
P van Ulsen1, M Hillebrand, L Zulianello
1Laboratory of Molecular Genetics, Leiden University, The Netherlands.
Journal of Bacteriology
|May 1, 1997
Abstract:
Inversion of the ihf site in the promoter region of the early promoter of bacteriophage Mu did not influence the integration host factor (IHF)-mediated functions. IHF bound to this inverted site could counteract H-NS-mediated repression, directly activate transcription, and support lytic growth of bacteriophage Mu. This implies that the IHF heterodimer and its asymmetrical binding site form a functionally symmetrical complex.