Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Impulse response analysis of baroreceptor sensitivity

R B Panerai1, M A James, J F Potter

  • 1Division of Medical Physics, Faculty of Medicine, University of Leicester, Leicester Royal Infirmary, United Kingdom.

The American Journal of Physiology
|April 1, 1997
PubMed
Summary

The impulse response function (IRF) offers a novel, objective method to assess baroreceptor sensitivity (BRS). This technique, correlating well with existing measures, shows reduced BRS in hypertensive individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated estimation of the logistic curve model of cerebral CO<sub>2</sub> vasomotor reactivity.

Journal of clinical monitoring and computing·2026
Same author

The impact of posture changes on critical closing pressure and resistance-area product regulation in healthy subjects.

European journal of applied physiology·2025
Same author

Assessing discards in an illegal small-scale fishery using fisher-led reporting.

Reviews in fish biology and fisheries·2022
Same author

INFOMATAS multi-center systematic review and meta-analysis individual patient data of dynamic cerebral autoregulation in ischemic stroke.

International journal of stroke : official journal of the International Stroke Society·2020
Same author

Estimated glomerular filtration rate and risk of poor outcomes after stroke.

European journal of neurology·2019
Same author

Inter-subject analysis of transfer function coherence in studies of dynamic cerebral autoregulation.

Physiological measurement·2018

Area of Science:

  • Physiology
  • Cardiovascular Research
  • Biomedical Engineering

Background:

  • Baroreceptor sensitivity (BRS) is crucial for cardiovascular regulation.
  • Existing BRS assessment methods have limitations, including subjective data selection.
  • The impulse response function (IRF) models dynamic physiological relationships.

Purpose of the Study:

  • To evaluate the impulse response function (IRF) as an alternative, objective method for assessing baroreceptor sensitivity (BRS) in humans.
  • To compare IRF-derived BRS with established BRS measurement techniques.
  • To investigate BRS differences between normotensive and hypertensive individuals using IRF.

Main Methods:

  • Noninvasive recordings of systolic arterial pressure (SAP) and pulse interval (PI) were obtained.

Related Experiment Videos

  • IRF was calculated via the inverse Fourier transform of the transfer function between PI and SAP.
  • BRS was also assessed using phenylephrine/sodium nitroprusside challenges and spectral analysis (alpha-index).

    • Main Results:

    • The IRF's temporal pattern showed a distinct peak and trough.
    • IRF peak values significantly correlated with alpha-index, BRS(PE), and BRS(SNP).
    • Hypertensive subjects exhibited significantly reduced IRF-derived BRS compared to normotensive subjects.

    Conclusions:

    • The impulse response function (IRF) provides a reliable and objective measure of baroreceptor sensitivity (BRS).
    • IRF assessment eliminates the need for subjective data segment preselection or spectral band choices.
    • IRF represents a promising, potentially ideal, method for BRS evaluation in clinical settings.