Age might influence the frequency distribution of metoprolol hydroxylation polymorphism in a Chinese population

The frequency distribution of the 8-hour urinary ratio of metoprolol/alpha-hydroxymetoprolol (MR) was investigated in 206 healthy rural Chinese volunteers. The frequency of the poor metabolizer phenotype of metoprolol alpha-hydroxylation was 0% in this Chinese population. When the 206 subjects were subgrouped into four groups by age, the excretion of alpha-hydroxymetoprolol was significantly lower in the subjects with age older than 41 years compared to two younger groups (16-30 years), and the metoprolol hydroxylation metabolic ratio(metoprolol/a-hydroxymetoprolol, MR) was higher in these middle-aged subjects, indicating that age may affect the frequency distribution of the 8-hour urinary MR or log MR, although multiple regression analysis did not show a significant correlation between age, urine volume and MR. Also, a significant correlation was found between age and the excretion (percentage of dose) of alpha-hydroxymetoprolol in 8-hour urine (r = 0.259, P < 0.001). On the other hand, both multiple regression analysis and nonparametric tests showed that the larger the amount of urine excreted, the more metoprolol was recovered, demonstrating that the urinary excretion of unchanged metoprolol is renal flow-limited.