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Is CD46 the cellular receptor for measles virus?
1Institut National de Sante et de la Recherche Médicale U. 404 Immunité et Vaccination, Institut Pasteur de Lyon, France.
Abstract:
Although CD46 would appear to be the cellular receptor for vaccine strains of measles virus (MV), recently there has been an accumulation of data suggesting that CD46 does not play this role for MV wild-type strains. Clarification of the nature of the MV receptor is necessary for the development of more effective vaccines against this virus which is responsible for the deaths of nearly two million children each year in the Third World.
Insights
Identifying the measles virus (MV) receptor is crucial for developing better vaccines. Current research suggests CD46 may not be the primary receptor for wild-type MV strains, necessitating further investigation.
Area of Science:
- Virology
- Immunology
- Vaccinology
Background:
- Measles virus (MV) causes significant global child mortality.
- CD46 has been considered the cellular receptor for MV vaccine strains.
- Emerging data challenges CD46's role as the receptor for wild-type MV.
Purpose of the Study:
- To clarify the cellular receptor for wild-type measles virus.
- To inform the development of more effective MV vaccines.
Main Methods:
- The study reviews existing data on MV-host interactions.
- Comparative analysis of receptor usage by MV vaccine and wild-type strains.
Main Results:
- Evidence suggests CD46 is not the primary receptor for wild-type MV.
- The specific receptor for wild-type MV remains to be definitively identified.
Conclusions:
- Accurate identification of the MV receptor is critical for vaccine advancement.
- Further research is needed to elucidate the wild-type MV receptor and improve global health outcomes.