Ten years of the cytogenetics of soft tissue tumors

Recent cytogenetic and molecular genetic investigations in solid tumors in general, and in soft tissue tumors in particular, have provided us with a wealth of information. We have gained new insights in how tumors may arise, and some soft tissue tumors besides their identification by pathology now also have a genetic identity. This genetic identity is defined by: specific chromosome changes and by molecular changes related to the chromosome anomalies. However, much work remains to be done. In soft tissues as in other solid tumors many tumor types await the first or more extensive chromosome investigation, and in those in which nonrandom, especially simple chromosome changes emerge, molecular studies are to be undertaken starting from the breakpoints. Those tumors that seem to deviate chromosomally or molecularly from the expected, because of already established genetic changes, must be more thoroughly investigated by both pathologists and geneticists. The same accounts for the molecular investigation of chromosomally normal tumors known to show subtypes with specific chromosomal changes: e.g. lipoma, leiomyoma.