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The effect of methamphetamine on histamine release in the rat hypothalamus
C Ito1, K Onodera, A Yamatodani
1Department of Psychiatry, Tohoku University School of Medicine, Sendai, Japan.
Psychiatry and Clinical Neurosciences
|April 1, 1997
Abstract:
In the present study, the effect of methamphetamine (MAP) on histamine (HA) release measured by in vivo brain microdialysis in the rat hypothalamus was investigated. Administration of MAP (3 mg/kg) significantly increase HA release from 40 to 160 min after the injection. This finding suggests that a moderate dose of MAP activates the hypothalamic HA neuron system, which may be related to effects of MAP on intrinsic biological rhythms.