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Pentavalent antimonial-induced torsade de pointes
J Ortega-Carnicer1, R Alcázar, M De la Torre
1Intensive Care Unit, Hospital Alarcos, Ciudad Real, Spain.
Journal of Electrocardiology
|April 1, 1997
Summary
Pentavalent antimonial drugs, used for visceral leishmaniasis, can cause fatal ventricular arrhythmias. This case documents torsade de pointes and QT interval prolongation linked to meglumine antimoniate treatment.
Area of Science:
- Cardiology
- Infectious Diseases
- Pharmacology
Background:
- Pentavalent antimonial drugs are standard treatment for visceral leishmaniasis.
- Sudden deaths have been anecdotally linked to these drugs, suspected to be due to cardiac arrhythmias.