[Cytology of reversible and irreversible epithelial changes in the uterine cervix]

The etiology and the experimentally founded concept of pathogenesis of reversible and irreversible epithelial changes of the cervix uteri are described. The possibilities and limitations of differential diagnosis of dysplasia, carcinoma in situ, and invasive carcinoma are discussed. Cytological criteria of differential diagnosis are mentioned and summarized in table form. Rates of regression, persistence and progression of different forms of dysplasia as potential forerunners of invasive carcinoma are mentioned. By the use of all cytological parameters a primary differential diagnosis of the mentioned lesions may be reached to a degree of 90% (Patten 1969; Wied et al. 1976). Diagnostic findings should be precisely formulated to give the best information for further diagnostic or therapeutic procedures concerning the individual case.