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Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
Interaction of ciprofloxacin with diclofenac and paracetamol in relation to it's epileptogenic effect
M P Shrivastava1, S D Makde, B D Paranjpe
1Department of Pharmacology, Government Medical College, Nagpur.
Abstract:
A number of fluoroquinolones have shown convulsive potential. The effect of Ciprofloxacin was studied in electroconvulsive seizures in mice using the tonic extensor phase as end point and seizure threshold as observational parameter. Its interaction with diclofenac and paracetamol was also studied. It was found that Ciprofloxacin produced a significant epileptogenic effect. This was potentiated by diclofenac but paracetamol had no such effect. Though the exact mechanisms involved in this effect are conjectural, role of GABA inhibitory mechanisms is a possibility.
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