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Genetic analyses of emotionality

T C Eley1, R Plomin

  • 1Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, 113 Denmark Hill, London, SE5 8AF, UK. t.eley@iop.bpmf.ac.uk

Current Opinion in Neurobiology
|April 1, 1997
PubMed
Summary

Genetic factors significantly influence emotionality in both animals and humans. Ongoing molecular research is identifying specific genes linked to neuroticism, anxiety, and depression.

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Area of Science:

  • Behavioral genetics
  • Molecular genetics
  • Psychiatric genetics

Background:

  • Quantitative genetic studies consistently demonstrate a heritable component to emotionality across species.
  • Emotional traits like neuroticism, anxiety, and depression are complex phenotypes influenced by multiple genetic and environmental factors.

Purpose of the Study:

  • To review the current understanding of genetic influences on emotionality.
  • To highlight advances in molecular genetics for identifying specific genetic loci associated with emotional domains.

Main Methods:

  • Synthesis of findings from quantitative genetic research.
  • Overview of molecular genetic studies identifying quantitative trait loci (QTLs).

Main Results:

  • Consistent evidence for significant genetic contributions to emotionality.
  • Emerging identification of specific quantitative trait loci associated with neuroticism, anxiety, and depression.

Conclusions:

  • Genetic factors play a crucial role in the etiology of emotionality.
  • Molecular genetics provides powerful tools for dissecting the genetic architecture of emotional traits and related disorders.

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