Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Infectious complications of hepatic cryosurgery

D K Riley1, T J Babinchak, R Zemel

  • 1Department of Medicine, Allegheny General Hospital, Medical College of Pennsylvania, and Hahnemann University, Pittsburgh, 15212, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|May 1, 1997
PubMed
Summary

Hepatic cryosurgery for liver metastases can cause infections like abscesses and cholangitis, primarily linked to gastrointestinal cancers. Avoiding biliary tree manipulation may reduce these risks, with overall cryoablation not increasing infection risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacokinetics, safety and efficacy of a recombinant factor IX product, trenonacog alfa in previously treated haemophilia B patients.

Haemophilia : the official journal of the World Federation of Hemophilia·2017
Same author

Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity.

Journal of viral hepatitis·2012
Same author

How the overlapping timescales for peptide binding and terrace exposure lead to non-linear step dynamics during growth of calcium oxalate monohydrate.

Crystal growth & design·2010
Same author

Impact of different factors on the probability of clinical response in tigecycline-treated patients with intra-abdominal infections.

Antimicrobial agents and chemotherapy·2009
Same author

Subnanometer atomic force microscopy of peptide-mineral interactions links clustering and competition to acceleration and catastrophe.

Proceedings of the National Academy of Sciences of the United States of America·2009
Same author

Immunohistochemical evaluation of hepatic oval cell activation and differentiation toward pancreatic beta-cell phenotype in streptozotocin-induced diabetic mice.

Journal of molecular histology·2008

Area of Science:

  • Hepatobiliary Surgery
  • Interventional Radiology
  • Oncology

Background:

  • Hepatic cryosurgery is an emerging treatment for liver metastases.
  • Infectious complications of this procedure have not been previously reviewed.
  • Gastrointestinal malignancies are the primary indication for hepatic cryosurgery.

Purpose of the Study:

  • To review and analyze infectious complications following hepatic cryosurgery.
  • To identify common pathogens and risk factors associated with these infections.
  • To evaluate the overall infection risk associated with liver cryoablation.

Main Methods:

  • Retrospective review of 158 hepatic cryosurgical procedures performed between November 1987 and July 1995.
  • Analysis of patient data, including diagnoses, procedures, and post-operative outcomes.

Related Experiment Videos

  • Identification and categorization of all directly related infectious complications.

    • Main Results:

    • Twelve infectious complications were directly attributed to hepatic cryosurgery.
    • Common infections included hepatic abscess (6), intraperitoneal abscess (3), and ascending cholangitis (2).
    • Enterococcus was the most frequent organism isolated, with 7 infections being polymicrobial.

    Conclusions:

    • Hepatic cryosurgery can lead to specific infectious complications, notably abscesses and cholangitis.
    • Patients experiencing infections had significantly longer hospital stays and more febrile days.
    • Minimizing perioperative biliary tree manipulation may further decrease infection rates; overall cryoablation does not elevate infection risk.