Related Experiment Video
Updated: Aug 19, 2026

Models of Bone Metastasis
Published on: September 4, 2012
Bisphosphonate therapy in metastatic breast cancer
1Department of Oncology, University of Helsinki, Finland.
Abstract:
Five long-term controlled studies on the effect of supportive bisphosphonate treatment in metastatic breast cancer with bone metastases have been published. In two of the studies pamidronate was used and in three clodronate. According to these trials supportive bisphosphonate treatment in metastatic breast cancer diminishes the risk of malignant, pathological fractures and bone pain. In several of these trials a retarding effect on the progression of previous and new bone metastases could also be documented. One further large trial, hitherto published only in abstract form, indicates that the development of bone invasion can also be retarded by bisphosphonate treatment in patients with metastatic breast cancer without bone metastases.
More Related Videos
07:00Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
Published on: September 26, 2016
06:00Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
Published on: September 13, 2017
Related Concept Videos
Bone Remodeling
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...