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Related Experiment Videos

Brachytherapy in primary ocular tumors

J E Freire1, P De Potter, L W Brady

  • 1Department of Radiation Oncology, Allegheny University Hospital, Hahnemann Division, Philadelphia, Pennsylvania 19102, USA.

Seminars in Surgical Oncology
|May 1, 1997
PubMed
Summary

Plaque brachytherapy using Iodine-125 (I-125) offers an alternative to enucleation for ocular tumors like choroidal melanoma and retinoblastoma, preserving vision in many patients.

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Area of Science:

  • Ophthalmology
  • Radiation Oncology
  • Medical Physics

Background:

  • Primary ocular tumors, including choroidal melanoma and retinoblastoma, are rare but serious conditions.
  • Historically, enucleation was the primary treatment, often resulting in vision loss.
  • Current treatment trends emphasize organ preservation and visual acuity retention.

Purpose of the Study:

  • To review plaque brachytherapy techniques, diagnosis, staging, and literature for primary ocular tumors.
  • To highlight Iodine-125 (I-125) as a key isotope in plaque brachytherapy.
  • To discuss the efficacy of plaque brachytherapy in managing choroidal melanoma and retinoblastoma.

Main Methods:

  • Review of pertinent literature on plaque brachytherapy for ocular tumors.

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  • Discussion of techniques, diagnosis, and staging of choroidal melanoma and retinoblastoma.
  • Analysis of outcomes from studies utilizing Iodine-125 (I-125) plaque brachytherapy.

    • Main Results:

    • Plaque brachytherapy with I-125 is an effective alternative to enucleation for ocular tumors.
    • Recurrence rates after plaque therapy are approximately 15%, with higher rates for metastatic disease at 15 years.
    • Nondiffuse iris melanoma has a 93% control rate with custom I-125 plaques.
    • Plaque brachytherapy is used for retinoblastoma, either as primary therapy or post-external beam radiation.

    Conclusions:

    • Plaque brachytherapy, particularly with I-125, enables enucleation avoidance in most ocular tumor cases.
    • This technique facilitates vision preservation for a significant number of patients.
    • It represents a significant advancement in the management of choroidal melanoma and retinoblastoma.