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Published on: August 17, 2017
Risk factors for hip fracture in men. Hip Fracture Study Group
J A Grisso1, J L Kelsey, L A O'Brien
1Center for Clinical Epidemiology and Biostatistics, School of Medicine, University of Pennsylvania, Philadelphia 19104-6021, USA.
American Journal of Epidemiology
|May 1, 1997
Summary
Low body mass, limb dysfunction, and certain medications increase men's hip fracture risk. Regular physical activity is protective, suggesting it as a key preventive measure for reducing hip fractures in men.
Area of Science:
- Gerontology
- Epidemiology
- Orthopedics
Background:
- Hip fractures pose a significant health risk to men, with limited understanding of specific contributing factors.
- Identifying modifiable and non-modifiable risk factors is crucial for developing effective prevention strategies.
Purpose of the Study:
- To investigate potential risk factors associated with hip fractures in men.
- To evaluate the role of lifestyle, medication, and physical condition in hip fracture incidence.
Main Methods:
- A case-control study was conducted with 356 men experiencing their first hip fracture and 402 controls.
- Data on potential risk factors were collected through personal interviews across multiple hospital sites.
- Frequency matching by age and geographic indicators was used to select control participants.
Main Results:
- Men in the lowest body mass quintile had a significantly higher risk of hip fracture (OR 3.8).
- Premorbid lower limb dysfunction (OR 3.4), cimetidine use (OR 2.5), and psychotropic drug use (OR 2.2) were associated with increased risk.
- Cigarette/pipe smoking increased risk independently of body mass, while prior physical activity was protective.
Conclusions:
- Low body mass, lower limb dysfunction, and specific medications (cimetidine, psychotropic drugs) are significant risk factors for hip fracture in men.
- Physical activity demonstrates a protective effect, highlighting its importance in hip fracture prevention strategies for men.
- Further research on cimetidine's impact on osteoporosis and fractures is warranted.
