Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Substance abuse and bone marrow transplant

G Chang1, J H Antin, E J Orav

  • 1Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. GChang@Bics.BWH.Harvard.edu

The American Journal of Drug and Alcohol Abuse
|May 1, 1997
PubMed
Summary

Lifetime substance abuse negatively impacts survival rates for patients undergoing bone marrow transplant (BMT). This finding held true even after accounting for factors like smoking and transplant type.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An evaluation of a healthy participant laboratory model of epidural hyperthermia: a physiological study.

International journal of obstetric anesthesia·2024
Same author

[High-fat intake alleviates lung injury induced by <i>Paragonimus proliferus</i> infection in rats through up-regulating CYP 4A1 expression in lung tissues].

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control·2023
Same author

Effects of Vitamin D, Omega-3 Fatty Acids and a Home Exercise Program on Prevention of Pre-Frailty in Older Adults: The DO-HEALTH Randomized Clinical Trial.

The Journal of frailty & aging·2023
Same author

Iron Deficiency and Incident Infections among Community-Dwelling Adults Age 70 Years and Older: Results from the DO-HEALTH Study.

The journal of nutrition, health & aging·2022
Same author

Effects of residual feed intake divergence on growth performance, carcass traits, meat quality, and blood biochemical parameters in small-sized meat ducks.

Poultry science·2022
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Society, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, London, Ont. Sept. 15-18, 2011.

Canadian journal of surgery. Journal canadien de chirurgie·2022

Area of Science:

  • Hematology
  • Oncology
  • Addiction Medicine

Background:

  • Bone marrow transplant (BMT) is a critical treatment for various hematologic and oncologic conditions.
  • The long-term outcomes of BMT can be influenced by patient-specific factors, including substance abuse history.
  • Understanding the impact of substance abuse on BMT survival is crucial for comprehensive patient care.

Purpose of the Study:

  • To investigate the association between lifetime substance abuse (SA) and survival outcomes in patients following bone marrow transplant (BMT).
  • To test the hypothesis that a history of substance abuse adversely affects survival post-BMT.

Main Methods:

  • Retrospective study comparing 17 BMT patients with lifetime substance abuse to 17 matched controls without SA.
  • Patients were matched for disease, transplant type, conditioning regimen, and age.

Related Experiment Videos

  • Survival analysis utilized Kaplan-Meier curves and log-rank tests, with stratification for smoking and transplant type.

    • Main Results:

    • Substance abuse was confirmed in all 17 patients, with alcohol, marijuana, and opiates being the most common substances.
    • Patients with a history of substance abuse demonstrated significantly reduced survival times post-BMT (p = .0022).
    • This adverse association persisted after controlling for cigarette smoking and transplant type.

    Conclusions:

    • Lifetime substance abuse is linked to poorer survival outcomes in bone marrow transplant recipients.
    • These findings highlight the importance of addressing substance abuse in BMT patient management.
    • Further research may explore interventions to mitigate the negative impact of substance abuse on BMT survival.