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Dose dependent effects of yohimbine on methadone maintained patients
F A Hameedi1, S W Woods, M I Rosen
1Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
The American Journal of Drug and Alcohol Abuse
|May 1, 1997
Abstract:
Twelve methadone-maintained patients were randomized into a controlled crossover study with active and placebo yohimbine 20 mg once a day (n = 4), 5mg three times a day (n = 4) or 10 mg three times a day (n = 4) for seven days to evaluate the effect of yohimbine on naloxone precipitated opiate withdrawal. The yohimbine dose of 10 mg TID was well tolerated and was associated with an average decrease of 30% in precipitated withdrawal symptoms.