Response to dietary fat and cholesterol and genetic polymorphisms

1. We examined common polymorphisms in the genes encoding the LDL receptor, lipoprotein lipase, apoAI, apoB, apoAIV and cholesteryl ester transfer protein and related them to changes in LDL and HDL cholesterol after high fat/high cholesterol diets. 2. The only significant association was seen with the apoIV polymorphism, which leads to a structural change in the protein. The response to fat and cholesterol in subjects with at least one apoAIV 2 allele was only 30% of that seen in subjects with the common apoIV 1 allele (P < 0.01), accounting for 6-7% of the variance in response. This confirms the results of two previous studies in which dietary cholesterol intake was changed. 3. No association were seen with polymorphisms of the other five genes examined.