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Follicle-stimulating hormone activates a cAMP-dependent chloride conductance in TM4 Sertoli cells
A Jungwirth1, T Weiger, S K Singh
1Department of Urology, General Hospital Salzburg, Austria. a.jungwirth@lkasbg.gv.at
Biochemical and Biophysical Research Communications
|April 7, 1997
Abstract:
The effect of follicle-stimulating hormone (FSH) on the electrical properties of TM4-Sertoli cells was investigated. Addition of 5 IU/ml FSH caused a dose-dependent and reversible depolarization of the resting membrane potential by +15.3 +/- 1.0 mV accompanied by a decrease of the input resistance. The depolarization was completely abolished in chloride-free solutions. The reversal potential of the effect was close to the calculated reversal potential for chloride. We conclude that FSH activates a chloride conductance in cultured TM4 Sertoli cells.