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1-[3-(Aryloxy) propyl]-diamines: a new class of non-steroidal basic antiinflammatory agents. Structure-activity
1Department of Pharmaceutical Chemistry, School of Pharmacy University of Thessaloniki, Greece.
Research Communications in Molecular Pathology and Pharmacology
|March 1, 1997
Abstract:
Six substituted aryloxy diamines, synthesized as potential new antiinflammatory agents, were tested in vivo and in vitro in order to evaluate their biological activities. These derivatives reduced significant carrageenin rat paw edema and showed antiproteolytic activity. The in vitro inhibition of soybean lipoxygenase ranged from 41-77%. The results are discussed from the view of structural modifications.