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Evaluation of himachalol in murine invasive aspergillosis
L Chowdhry1, Z K Khan, D K Kulshrestha
1Division of Medical Mycology, Central Drug Research Institute, Lucknow, India.
Mycoses
|November 1, 1996
Abstract:
Himachalol (a sesquiterpene alcohol) showed low in vitro minimum inhibitory concentrations against Aspergillus fumigatus by the macro- and microbroth dilution techniques (genometric mean 250 micrograms ml-1 and 46.4 micrograms ml-1 respectively) compared with saperconazole. Swiss mice treated with the phytoproduct (200 mg kg-1, p.o.) once daily for 7 days exhibited a significant (P < 0.001) protection (60%) together with an increase in the mean survival time (15 days) and a reduced CFU (mean log10) burden of A. fumigatus in the kidneys.