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Related Experiment Videos

Will tolerance become a clinical reality?

S Aradhye1, L A Turka

  • 1Department of Medicine, University of Pennsylvania, Philadelphia 19104-6100, USA.

The American Journal of the Medical Sciences
|May 1, 1997
PubMed
Summary
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A role for plasma cell targeting agents in immune tolerance induction in autoimmune disease and antibody responses to therapeutic proteins.

Clinical immunology (Orlando, Fla.)·2016

Transplant physicians aim for antigen-specific tolerance to prevent graft rejection and lifelong immunosuppression. Current strategies leverage natural self-tolerance mechanisms, showing promise in animal models and clinical trials for transplantation tolerance.

Area of Science:

  • Immunology
  • Transplantation Medicine

Background:

  • Current immunosuppressive drugs prevent organ rejection but cause side effects and do not induce lasting tolerance.
  • Achieving antigen-specific tolerance is a key goal in transplantation to eliminate the need for long-term medical therapy.

Purpose of the Study:

  • To explore strategies for inducing antigen-specific transplantation tolerance.
  • To investigate the potential of natural self-tolerance mechanisms in achieving transplant success.

Main Methods:

  • Review of natural mechanisms of self-tolerance in vertebrates.
  • Application of these mechanisms in preclinical animal models.
  • Translation of successful strategies into ongoing clinical trials.

Main Results:

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  • Demonstrated progress in inducing transplantation tolerance in animal models.
  • Identification of natural self-tolerance pathways as viable therapeutic targets.

Conclusions:

  • Exploiting natural self-tolerance mechanisms offers a promising path toward achieving transplantation tolerance.
  • Clinical translation of these strategies presents both opportunities and challenges for the future of organ transplantation.