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Related Experiment Videos

Studies on the interaction between water and (hydroxypropyl)methylcellulose

A Nokhodchi1, J L Ford, M H Rubinstein

  • 1Pharmaceutical Technology and Drug Delivery Group, School of Pharmacy and Chemistry, Liverpool John Moores University, UK.

Journal of Pharmaceutical Sciences
|May 1, 1997
PubMed
Summary

This study analyzed moisture sorption in hydroxypropyl methylcellulose (HPMC) grades. Larger particle sizes increased external moisture adsorption, impacting tablet properties.

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Area of Science:

  • Materials Science
  • Physical Chemistry
  • Pharmaceutical Science

Background:

  • Hydroxypropyl methylcellulose (HPMC) is a widely used polymer in pharmaceutical formulations.
  • Understanding its moisture sorption behavior is critical for predicting drug product stability and performance.
  • The influence of particle size and viscosity on HPMC's interaction with water requires detailed investigation.

Purpose of the Study:

  • To analyze the moisture sorption and desorption profiles of different viscosity grades and particle sizes of HPMC 2208.
  • To elucidate the distribution of sorbed moisture (monolayer, external, internal) using Young and Nelson equations.
  • To correlate moisture sorption characteristics with the mechanical properties of HPMC K4M tablets.

Main Methods:

  • Moisture sorption/desorption analysis using Young and Nelson equations.

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  • Differential scanning calorimetry (DSC) to determine nonfreezing and freezing water content.
  • Mechanical testing (tensile strength, yield pressure, elastic recovery) of HPMC K4M tablets.

    • Main Results:

    • Increased particle size led to reduced internal moisture absorption and increased external adsorption, particularly for lower viscosity HPMC grades (K100, K4M).
    • HPMC K100M exhibited the lowest internally absorbed moisture.
    • Changes in tablet mechanical properties correlated with variations in internally and externally adsorbed moisture.
    • Water:HPMC ratio positively influenced the enthalpy of water melting, while nonfreezable water remained constant across viscosity grades and particle sizes.

    Conclusions:

    • Particle size and viscosity significantly modulate moisture sorption locations in HPMC.
    • The distribution of sorbed water influences the physical properties of HPMC-based tablets.
    • Nonfreezable water content is independent of HPMC viscosity grade and particle size, suggesting a stable bound water fraction.