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Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation
1Department of Interdisciplinary Studies on Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan.
Chemical & Pharmaceutical Bulletin
|April 1, 1997
Abstract:
Short-term in vitro assays for tumor promoters and antitumor promoters (Epstein-Barr virus activation test) were carried out for semisynthetic quassinoids (3-7), which were obtained by esterification of the C-15 OH group of deacetylated isobrucein-B (2). All the ester derivatives showed higher antitumor promoting activity than that of the potent compound 2. A compound containing a fluorinated aliphatic ester showed the highest potency.