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Recognition of osteopontin by rat bone marrow derived osteoblastic primary cells
1Bionic Design Group, National Institute for Advanced Interdisciplinary Research (NAIR), Tsukuba Research Center, Ibaraki, Japan.
Bioscience, Biotechnology, and Biochemistry
|April 1, 1997
Abstract:
To study the role of osteopontin, we did cell adhesion and ALP assays of rat bone marrow osteoblastic cells (RBMO) on collagen Type I and osteopontin surfaces. The RBMO proved to adhere much more strongly to the osteopontin and to have higher ALP activity on the osteopontin, which suggests that pre-osteoblasts differentiate into osteoblasts that form bone by recognizing osteopontins.