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The Interstitial Cystitis Data Base Study: concepts and preliminary baseline descriptive statistics

L J Simon1, J R Landis, D R Erickson

  • 1Department of Urology, Pennsylvania State University College of Medicine, Hershey 17033-0850, USA.

Urology
|May 1, 1997
PubMed
Summary
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The Interstitial Cystitis Data Base (ICDB) Study reveals that patients with interstitial cystitis (IC) predominantly experience frequent urination, pain, and urgency, impacting their quality of life. This analysis provides a foundation for future IC research.

Area of Science:

  • Urology
  • Epidemiology
  • Clinical Research

Background:

  • Interstitial cystitis (IC) is a chronic condition affecting the bladder.
  • Previous epidemiological studies on IC have provided limited data on patient characteristics and symptom severity.

Purpose of the Study:

  • To detail the design, patient enrollment, and data collection of the Interstitial Cystitis Data Base (ICDB) Study.
  • To present preliminary descriptive statistics and initial findings from an interim analysis of the ICDB Study data.

Main Methods:

  • An interim analysis included 424 participants enrolled in the ICDB Study by December 31, 1995.
  • Participants were categorized into three symptom severity subgroups.
  • Mantal-Haenszel procedures were used to assess associations between baseline characteristics and symptom severity, adjusting for clinical center variations.

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Main Results:

  • The study population was predominantly female (91.5%) and white (91.0%), with an average age of 44.3 years.
  • Urodynamic findings showed an inverse relationship between bladder volumes at first sensation/maximal capacity and symptom severity.
  • High prevalence of symptoms including frequent urination (≥15 times/day for ~40%), nocturia (≥4 times/night for >20%), constant urgency (~48%), and severe pain (~24%) were reported.
  • Patients with severe symptoms reported significantly greater quality-of-life limitations.

Conclusions:

  • This interim analysis of the ICDB Study provides valuable baseline data for interstitial cystitis.
  • The findings establish a foundation for future investigations into the associations and longitudinal trends of IC.