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Related Experiment Videos

Hydroxyzine therapy for interstitial cystitis

T C Theoharides1, G R Sant

  • 1Department of Pharmacology / Experimental Therapeutics, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111, USA.

Urology
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

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Oral hydroxyzine shows promise for treating interstitial cystitis (IC) symptoms. Patients experienced significant symptom reduction, particularly those with allergies.

Area of Science:

  • Urology
  • Pharmacology

Background:

  • Interstitial cystitis (IC) is a chronic bladder condition causing pain and urinary urgency.
  • Current treatments for IC offer limited relief for many patients.

Purpose of the Study:

  • To evaluate the effectiveness of oral hydroxyzine in managing symptomatic interstitial cystitis.
  • To assess the impact of hydroxyzine on IC symptom severity.

Main Methods:

  • An open-label, nonconsecutive case series involving patients treated by local physicians.
  • Outcomes were assessed using case-report forms and visual analog scales for symptom scoring.

Main Results:

  • Out of 140 patients, 90 (65%) completed the study.
  • A 40% average reduction in symptom scores was reported.

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  • Patients with a history of allergies showed a greater improvement, with a 55% reduction in symptoms.

    • Conclusions:

    • Oral hydroxyzine is a beneficial treatment option for symptomatic interstitial cystitis (IC).
    • The drug is particularly effective in patients with allergies or evidence of bladder mast cell activation.