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Polymorphic changes of mannitol during freeze-drying: effect of surface-active agents
R Haikala1, R Eerola, V P Tanninen
1Orion Pharma, Espoo, Finland.
PDA Journal of Pharmaceutical Science and Technology
|March 1, 1997
Abstract:
The effect of polysorbate 80 on the crystalline properties of mannitol during freeze-drying was studied. Crystallinity and polymorphism play an important role in, e.g., the solubility and stability of freeze-dried products. Polysorbate 80 had an effect on both the polymorphism and the crystallinity of freeze-dried mannitol.