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Acyclovir-induced colitis

T D Wardle1, J P Finnerty, V Swale

  • 1Department of Medicine, Countess of Chester Hospital, Liverpool, UK.

Alimentary Pharmacology & Therapeutics
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

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Oral acyclovir, used for herpes infections, may cause acute colitis in some patients. A repeat dose in one individual confirmed this link, suggesting a direct irritant effect on the colon.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Acyclovir is a widely used antiviral medication for herpes simplex virus and varicella-zoster virus infections.
  • Colitis is an inflammation of the colon.

Observation:

  • Three patients presented with acute colitis following oral acyclovir administration.
  • Colitis occurred either as a new condition (de novo) or an exacerbation of pre-existing colitis.

Findings:

  • Recurrent colitis symptoms were observed in one patient upon rechallenge with oral acyclovir.
  • These findings suggest a potential causal link between oral acyclovir and the development of colitis.

Implications:

  • Acyclovir may possess a direct irritant effect on the colonic mucosa.

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  • Clinicians should consider acyclovir as a potential cause of acute colitis in patients presenting with relevant symptoms.