Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mucosal prolapse changes in Hirschsprung's disease

R Chetty1, D Govender

  • 1Department of Anatomical Pathology, University of Natal School of Medicine, Durban, South Africa.

Histopathology
|April 1, 1997
PubMed
Summary

Mucosal prolapse changes occur in Hirschsprung

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transforming communication across surgical generations - bridging the gap.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2025
Same author

A quick, easy and efficient protocol for extracting high-quality RNA from Mycobacterium tuberculosis using a spin column commercial kit.

BMC research notes·2023
Same author

Immunohistochemical determination of mismatch repair gene product in colorectal carcinomas in a young indigenous African cohort.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2022
Same author

Neuroendocrine neoplasms of the digestive tract: incorporating the 2019 WHO grading schema in the South African context.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2021
Same author

Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.

Scientific reports·2018
Same author

The T-box transcription factor 3 is a promising biomarker and a key regulator of the oncogenic phenotype of a diverse range of sarcoma subtypes.

Oncogenesis·2016

Area of Science:

  • Gastroenterology and Pathology

Background:

  • Hirschsprung's disease is a congenital condition affecting the large intestine.
  • Mucosal prolapse is a recognized complication.

Purpose of the Study:

  • To determine the incidence and histological characteristics of mucosal prolapse in Hirschsprung's disease.

Main Methods:

  • Analysis of 23 resection specimens from patients with Hirschsprung's disease.
  • Histological examination for features of mucosal prolapse at the ganglionic-aganglionic junction.

Main Results:

  • Eight out of 23 cases (34.8%) showed histological evidence of mucosal prolapse.
  • Key features included thickened muscularis mucosae, metaplastic/hyperplastic tubules, goblet cell and cryptal hypertrophy, increased elastic fibers, and diamond-shaped glands.
  • Prolapse was more pronounced in older patients, suggesting a link to symptom duration.

Conclusions:

  • Mucosal prolapse is a histological finding in a significant proportion of Hirschsprung's disease cases.
  • Histological features are distinct and related to duration of symptoms.
  • Differential pressures, fecal stream, and straining are implicated in its pathogenesis.

Related Experiment Videos