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Updated: Aug 15, 2026

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation
Published on: December 31, 2007
Abstract:
This essay offers a highly biased and prejudiced interpretation of the immune response. The major points of this interpretation are: B and T lymphocyte diversity is generated by rearrangements within and among existing receptorcoding genes; the T cell receptor is a molecule genetically more closely related to immunoglobulins than to the products of the major histocompatibility complex (MHC); the course of B and T lymphocyte differentiation is largely the same except for a final processing of T lymphocytes in the thymus; the processing is directed by MHC molecules of the thymus epithelium; Ir and Ia genes are identical; and the function of MHC polymorphism is to generate diversity at the population level.
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