Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparing two diagnostic tests against the same "gold standard" in the same sample

D A Bloch1

  • 1Department of Health Research and Policy, Stanford University School of Medicine, California 94305-5092, USA.

Biometrics
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety and efficacy of retreatment with a bioengineered hyaluronate for painful osteoarthritis of the knee: results of the open-label Extension Study of the FLEXX Trial.

Osteoarthritis and cartilage·2011
Same author

Safety issues in the development of treatments for osteoarthritis: recommendations of the Safety Considerations Working Group.

Osteoarthritis and cartilage·2011
Same author

Lymphoma and luekemia in rheumatoid arthritis: are they associated with azathioprine, cyclophosphamide, or methotrexate?

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
Same author

Study of redox potential in cytochrome c covalently bound to terminal oxidase of alkaliphilic Bacillus pseudofirmus FTU.

Biochemistry. Biokhimiia·2008
Same author

Design and conduct of clinical trials in patients with osteoarthritis of the hand: recommendations from a task force of the Osteoarthritis Research Society International.

Osteoarthritis and cartilage·2006
Same author

Effect of reproductive factors and postmenopausal hormone use on the risk of Parkinson disease.

Neurology·2005
Same journal

Fast penalized generalized estimating equations for large longitudinal functional datasets.

Biometrics·2026
Same journal

Causally-interpretable random-effects meta-analysis.

Biometrics·2026
Same journal

Statistical inference for mean function of partially observed functional time series.

Biometrics·2026
Same journal

Subgroup identification via Interaction Tree and Mixed Model for Repeated Measures with application to Alzheimer's disease.

Biometrics·2026
Same journal

Finite mixtures of linear quantile regressions with concomitant variables: a solution to endogeneity in longitudinal data modeling.

Biometrics·2026
Same journal

Discussion on "INTACT: a method for integration of longitudinal physical activity data from multiple sources" by Jingru Zhang, Erjia Cui, Hongzhe Li, and Haochang Shou.

Biometrics·2026
See all related articles

This study introduces methods to compare diagnostic tests, contrasting estimated risks and kappa coefficients. It provides statistical approaches for analyzing test performance with specified thresholds, aiding in diagnostic accuracy assessment.

Area of Science:

  • Medical Diagnostics
  • Biostatistics
  • Health Services Research

Background:

  • Comparing the performance of multiple diagnostic tests is crucial for clinical decision-making.
  • Existing methods may not adequately address scenarios with pre-specified or data-driven thresholds.

Purpose of the Study:

  • To propose and illustrate statistical methods for comparing two diagnostic tests on the same dataset.
  • To provide a framework for evaluating diagnostic accuracy when thresholds are fixed or determined from data.

Main Methods:

  • Contrasting estimated risks between diagnostic tests.
  • Comparing kappa coefficients to assess agreement.
  • Deriving maximum likelihood estimators and asymptotic variances for a priori thresholds.
  • Utilizing the bootstrap method for risk estimator comparisons with data-scanned thresholds.

Related Experiment Videos

Main Results:

  • The study presents test statistics for both case-control and naturalistic sampling.
  • Methods are demonstrated with examples for practical application.
  • The proposed methods allow for robust comparison of diagnostic test performance.

Conclusions:

  • The developed methods offer a statistically sound approach to comparing diagnostic tests.
  • These techniques are valuable for selecting the most accurate diagnostic tools.
  • The study facilitates improved diagnostic accuracy evaluation in various sampling designs.