Population variation at the polymorphic ApaLI restriction enzyme site in intron 5 of the WT1 gene
C Besnard-Guérin1, R Winqvist, I Newsham
1Ludwig Institute for Cancer Research, La Jolla, CA 93093-0660, USA.
Abstract:
We examined 63 unrelated individuals from the United States for the Apa-LI polymorphism in intron 5 of the WT1 gene. Allele frequencies of 0.13 and 0.87 for the A and B alleles, respectively, and a heterozygosity index of 24% contrast sharply with previous data obtained in the Japanese population where allele frequencies of 0.55 and 0.45 for the A and B alleles and a heterozygosity index of 59% were reported. These data suggest genetic heterogeneity at the WT1 locus, which may contribute to the differences in the incidence of Wilms tumor between the two population groups.
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