Related Experiment Video
Updated: Aug 11, 2026
07:23
Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
Published on: December 3, 2016
Meyer's dysplasia epiphysealis
F Specchiulli1, L Scialpi, G Mastrorillo
1Clinica Ortopedica dell'Università, Bari.
La Chirurgia Degli Organi Di Movimento
|September 1, 1996
Summary
Meyer's femoral cephalic dysplasia (FCD) is a rare hip condition distinct from Perthes' disease. Key features include delayed ossification and a unique "morulated" epiphysis, impacting treatment and prognosis.
Area of Science:
- Pediatric Orthopedics
- Developmental Biology
Background:
- Meyer's femoral cephalic dysplasia (FCD) is a rare hip condition.
- It is often misdiagnosed as Perthes' disease, necessitating clear differentiation.
Observation:
- A hallmark of FCD is the absence of the nucleus of ossification until 15-18 months.
- The epiphysis may exhibit a "morulated" appearance due to multiple ossification centers.
- Epiphyseal fusion typically occurs around 5 years of age.
Findings:
- Unlike Perthes' disease, the epiphysis in FCD does not collapse.
- The density and structural integrity of the epiphysis are preserved in FCD.
Implications:
- Accurate diagnosis of FCD is crucial for appropriate treatment and prognosis.
- Differential diagnosis should exclude conditions like multiple dysplasia epiphysealis, hypothyroidism, and dyschondroplasia.
Related Concept Videos
01:16Bones of the Lower Limb: Femur and Patella
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the neck...
01:09Changes in the Appendicular Skeleton with Age
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
01:24Bone Formation by Endochondral Ossification
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
01:21Barrett Esophagus-I: Introduction
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
01:27Mitral Valve Prolapse I: Introduction
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
01:24Cellular Adaptation IV: Dysplasia and Metaplasia
DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...