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Updated: Aug 17, 2026

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
Published on: September 1, 2015
[Idiopathic CD4(+)-T-lymphocytopenia]
M J van de Ven1, J W Lenders, A A Baas
1Academisch Ziekenhuis, afd. Inwendige Geneeskunde, Nijmegen.
Abstract:
Three patients, two men aged 27 and 33 years and one woman aged 31 years, developed several opportunistic infections without presence of HIV infection. Patient A died after suffering Candida stomatitis, extrapulmonary Mycobacterium avium infection, cytomegalovirus infection and Aspergillus pneumonia; patient B recovered from a disseminated M. kansasii infection; patient C suffered from verrucae planae. These patients had CD4(+)-T lymphocytopenia, a shortage of helper T cells. Idiopathic CD4(+)-T lymphocytopenia is a heterogeneous pathological condition with normal serum immunoglobulin concentrations. Treatment consists of combating and preventing infections.
Insights
Idiopathic CD4 positive T lymphocytopenia, a T-cell deficiency without HIV, causes opportunistic infections. This condition requires careful management focused on preventing and treating infections.
Area of Science:
- Immunology
- Infectious Diseases
- Clinical Medicine
Background:
- Opportunistic infections can occur in individuals without HIV.
- CD4(+)-T lymphocytopenia, a decrease in helper T cells, is a known risk factor for infections.
- Idiopathic CD4(+)-T lymphocytopenia presents as a heterogeneous condition with normal immunoglobulin levels.
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