Spontaneous interictal spiking in the awake kindled rat

The spontaneous interictal spike (SIS) noted in EEG recordings is a signal of the abnormally excitable behavior of neurons in an epileptic focus. This study provides a detailed, quantitative, temporal and spatial profile of SIS in the amygdaloid kindled rat. The reproducible nature of the development and decline of SIS in kindling provides a useful model for biochemical study of the mechanisms that initiate and regulate SIS.