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Inhibitory effects on Epstein-Barr virus activation of anthraquinones: correlation with redox potentials
J Koyama1, K Tagahara, T Osakai
1Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Higashinada, Japan.
Cancer Letters
|May 19, 1997
Abstract:
The redox potentials have been determined for nine anthraquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the anthraquinones on the EBV-EA activation. It has further been shown that the correlation can be made better by introducing an electronic property, i.e. the atomic charge at O12 as an additional parameter.