Related Experiment Video
Updated: Aug 1, 2026
![Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F50301.jpg&w=3840&q=50)
12:24
Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Published on: March 23, 2013
Gastric emptying in hyperthyroidism
K Jonderko1, G Jonderko, C Marcisz
1Department of Physiology, Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland.
The American Journal of Gastroenterology
|May 1, 1997
Summary
Gastric emptying of solids in hyperthyroid patients is normal before and during treatment. After treatment normalizes thyroid levels (euthyroidism), gastric emptying speeds up slightly compared to healthy individuals.
Area of Science:
- Gastroenterology
- Endocrinology
- Nuclear Medicine
Background:
- Hyperthyroidism can affect gastrointestinal motility.
- Understanding gastric emptying is crucial for managing hyperthyroid patients.
Purpose of the Study:
- To investigate solid meal gastric emptying in hyperthyroid women.
- To assess changes in gastric emptying during thiamazole treatment and after achieving euthyroidism.
Main Methods:
- Prospective study of 11 hyperthyroid women and 12 healthy controls.
- Scintigraphic measurement of 99mTc-labeled solid meal emptying over 90 minutes.
- Analysis using a power-exponential model to determine gastric half-emptying time (t1/2), curve shape (S), and slope (K).
Main Results:
- Pretreatment gastric emptying in hyperthyroid patients was similar to controls.
- Gastric emptying remained unchanged during the third week of thiamazole treatment.
- A significant increase in gastric emptying rate (t1/2 and K) was observed after euthyroidism was restored.
Conclusions:
- Solid meal gastric emptying is not significantly different in hyperthyroid women compared to healthy controls.
- Pharmacological treatment with thiamazole does not alter gastric emptying rates.
- Euthyroidism is associated with a slight but significant increase in gastric emptying rate in previously hyperthyroid women.
More Related Videos
Related Concept Videos
01:29Intestinal Phase of Digestion
The intestinal phase of digestion is the third and final stage of the digestive process, occurring after the cephalic and gastric phases. It begins when chyme, a partially digested mixture of food and digestive enzymes, enters the small intestine from the stomach. This phase is crucial for nutrient absorption and involves complex hormonal and enzymatic interactions.
The arrival of the chyme in the small intestine distends the duodenum, which triggers the enterogastric reflex. This distension...
The arrival of the chyme in the small intestine distends the duodenum, which triggers the enterogastric reflex. This distension...
01:16Gastric Emptying
Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
01:26Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...
01:24Upper GI Series: Barium Swallow
The Barium Swallow Study, or a Barium Esophagogram, is a diagnostic imaging method used to visualize the upper gastrointestinal (GI) tract, including the esophagus, stomach, and small intestine. It employs barium sulfate, a radiopaque contrast material, to provide clear images of the upper digestive system, helping to identify abnormalities, diseases, or structural issues.
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
01:24Graves Disease II: Pathophysiology
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
01:11Pyloric Obstruction
Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...