Related Experiment Video
Updated: Jun 24, 2026

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases
Published on: September 29, 2014
Prevention of ACTH- and adrenalectomy-induced muricidal behavior: by benzodiazepinic ligands
1INSERM U52 CNRS ERS 5645, Faculte de Medecine Grange Blanche, Lyon, France.
Abstract:
We investigated the effect of treatment with central (neuronal and glial) benzodiazepine binding site-active molecules on ACTH- or adrenalectomy (ADX)-induced muricidal behavior in male Wistar rats. Pretreatment (IP) with either flumazenil or clonazepam prevented the subsequent induction of ADX-induced behavior, but only flumazenil protected against ACTH-induced behavior; posttreatment in both cases induced no significant modifications. Using 4'-chloro-diazepam or PK 11195, both pre- and posttreatment afforded protection, the effect lasting longer (> 1 week) than that induced by flumazenil or clonazepam (2 days). Pretreatment with the GABAA agonist, muscimol, also resulted in complete protection, whereas posttreatment had only a slight effect.
Related Concept Videos
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Cholinergic Antagonists: Therapeutic Uses
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal secretions in common...
Adrenergic Agonists: Therapeutic Uses
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions
Although all competitive neuromuscular blockers are designed...
Alzheimer's Disease: Treatment

