Related Experiment Videos
Kidney function in phasic insulin dependent diabetes mellitus in Jamaica
D Ragoobirsingh1, F Bennett, E Y Morrison
1Department of Biochemistry, University of the West Indies, Jamaica.
The West Indian Medical Journal
|March 1, 1997
Summary
Malnutrition-related diabetes mellitus (MRDM) patients in Jamaica show higher urinary microalbumin and serum creatinine levels, indicating significant kidney dysfunction. This suggests malnutrition precedes and exacerbates renal damage in phasic insulin-dependent diabetes mellitus (PIDDM).
Area of Science:
- Endocrinology
- Nephrology
- Nutritional Science
Background:
- Malnutrition-related diabetes mellitus (MRDM) in Jamaica is characterized by phasic insulin dependence.
- Nephropathic changes are a significant concern in diabetic populations worldwide.
- Understanding the specific renal impact of MRDM is crucial for targeted interventions.
Purpose of the Study:
- To investigate and compare nephropathic changes in phasic insulin-dependent diabetes mellitus (PIDDM) patients with other diabetes mellitus types and healthy controls.
- To identify potential causes of renal dysfunction in PIDDM, distinguishing it from other diabetic complications.
Main Methods:
- A comparative study involving 14 PIDDM patients, 10 insulin-dependent diabetes mellitus (IDDM) patients, 10 non-insulin-dependent diabetes mellitus (NIDDM) patients, and 10 normal controls.
- Groups were matched for age, sex, body mass index (BMI), and diabetes duration.
- Key parameters measured included urinary microalbumin concentration, serum urea, and serum creatinine levels.
Main Results:
- PIDDM patients exhibited significantly higher urinary microalbumin concentrations (153 +/- 48.3 mg/dl) compared to NIDDM (35.7 +/- 9.6 mg/dl) and IDDM (38.6 +/- 15.8 mg/dl) groups (p < 0.05).
- Serum urea and creatinine levels were also elevated in PIDDM patients (7.6 +/- 1.0 mmol/l and 130.0 +/- 20.3 mumol/l, respectively) compared to NIDDM and IDDM groups.
- Confounding factors like hypertension and urinary tract infections were ruled out.
Conclusions:
- PIDDM patients demonstrate more severe renal dysfunction than NIDDM and IDDM patients.
- Comparable glycosylated hemoglobin levels suggest the renal insult in PIDDM is primarily linked to malnutrition predating or concurrent with diabetes onset, rather than solely glycemic control.