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Related Experiment Videos

Left ventricular mass in the elderly. The Cardiovascular Health Study

J M Gardin1, A Arnold, J S Gottdiener

  • 1Department of Medicine, University of California, Irvine, USA. jgardin@uci.edu

Hypertension (Dallas, Tex. : 1979)
|May 1, 1997
PubMed
Summary
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Left ventricular mass, measured by echocardiography, is linked to cardiovascular disease risk factors in older adults. Key correlates include body weight, male sex, systolic pressure, and HDL cholesterol, influencing heart health outcomes.

Area of Science:

  • Cardiology
  • Gerontology
  • Medical Imaging

Background:

  • Left ventricular (LV) mass is an independent predictor of cardiovascular disease (CVD) morbidity and mortality.
  • Echocardiography (echo) is a primary method for estimating LV mass.

Purpose of the Study:

  • To evaluate the relationship between echocardiography-derived LV mass and CVD risk factors in an elderly cohort.
  • To identify demographic, clinical, and lifestyle factors associated with LV mass in older adults.

Main Methods:

  • Cross-sectional analysis of baseline data from the Cardiovascular Health Study (CHS) cohort.
  • Two-dimensionally directed M-mode echocardiography for LV mass measurement.
  • Stepwise and multiple linear regression analyses to assess associations with covariates.

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Main Results:

  • Body weight, male sex, systolic pressure, congestive heart failure, smoking, and hypertension treatment were positively associated with LV mass.
  • Diastolic pressure, bioresistance (adiposity), and high-density lipoprotein (HDL) cholesterol were inversely associated with LV mass.
  • Pulse pressure was a positive correlate, and HDL cholesterol an inverse correlate, of LV mass in this elderly cohort.

Conclusions:

  • LV mass in the elderly is associated with a range of demographic, cardiovascular risk, and lifestyle factors.
  • Understanding these associations is crucial for predicting changes in LV mass and its prognostic significance in older populations.