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Intraoperative mitomycin-C for glaucoma associated with ocular inflammation
M M Wright1, R F McGehee, J E Pederson
1Department of Ophthalmology, University of Minnesota, Minneapolis 55455, USA.
Background And Objective:
The authors studied the efficacy and complications of intraoperative mitomycin-C in glaucoma associated with ocular inflammation.
Patients And Methods:
The authors retrospectively reviewed the medical records of 24 consecutive patients (24 eyes) with glaucoma and ocular inflammation who had been treated with trabeculectomy and intraoperative mitomycin-C. Patient ages ranged from 10 to 83 years (mean 43 years). All patients were observed for at least 6 months.
Results:
With a mean follow-up time of 14.6 months, 18 of the 24 patients (75%) retained vision and had an intraocular pressure of 21 mm Hg or lower with or without medications (range 4 to 21 mm Hg; mean 13.4 mm Hg). Fifteen of 24 patients (62%) had an intraocular pressure of 21 mm Hg or lower with no medications. Three patients required tube shunt implants. One patient had a retinal detachment and lost light perception. One patient had endophthalmitis 14 months after surgery. Seven of 24 patients lost two or more lines of Snellen acuity.
Conclusion:
Trabeculectomy with mitomycin-C can control intraocular pressure in glaucoma associated with ocular inflammation, but complications are frequent.