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A new biologic membrane in cardiovascular surgery
A O Shawarby1, S Muralidharan, L B McGrath
1Department of Surgery, Temple University/Conemaugh's Memorial Medical Center, Johnstown, Pennsylvania 15905-4398, USA.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|May 1, 1997
Summary
Autologous peritoneum and rectus sheath effectively repaired cardiac defects in canines, showing potential as a biologic graft alternative to synthetic materials or pericardium.
Area of Science:
- Biomaterials Science
- Cardiovascular Surgery
- Regenerative Medicine
Background:
- Current cardiac defect repair relies on synthetic grafts or autogenic pericardium.
- A need exists for alternative, biocompatible materials for vascular and intracardiac reconstruction.
Purpose of the Study:
- To evaluate autologous abdominal parietal peritoneum and posterior rectus sheath as a biologic membrane for cardiovascular reconstruction.
- To assess the efficacy and safety of this composite membrane in repairing major vessels and intracardiac defects.
Main Methods:
- Harvesting of autologous parietal peritoneum and posterior rectus sheath from twelve adult canines.
- Repair of right ventricular outflow tract and pulmonary artery annuloplasty in six canines.
- Repair of surgically created secundum atrial septal defects in six canines under cardiopulmonary bypass.
Main Results:
- Post-operative autopsy at 90 days showed intact grafts without aneurysms or thrombi.
- Histological examination confirmed membrane integrity, cellular viability, and endothelialization.
- Mild intrapericardial adhesions and pericardial reactions were observed.
Conclusions:
- Autologous peritoneum and rectus sheath demonstrated successful application in repairing vascular and intracardiac defects.
- This biologic membrane shows promise as a substitute for pericardium in cardiac surgery.
- Further research is warranted prior to clinical application.