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Related Experiment Videos

A new biologic membrane in cardiovascular surgery

A O Shawarby1, S Muralidharan, L B McGrath

  • 1Department of Surgery, Temple University/Conemaugh's Memorial Medical Center, Johnstown, Pennsylvania 15905-4398, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|May 1, 1997
PubMed
Summary

Autologous peritoneum and rectus sheath effectively repaired cardiac defects in canines, showing potential as a biologic graft alternative to synthetic materials or pericardium.

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Area of Science:

  • Biomaterials Science
  • Cardiovascular Surgery
  • Regenerative Medicine

Background:

  • Current cardiac defect repair relies on synthetic grafts or autogenic pericardium.
  • A need exists for alternative, biocompatible materials for vascular and intracardiac reconstruction.

Purpose of the Study:

  • To evaluate autologous abdominal parietal peritoneum and posterior rectus sheath as a biologic membrane for cardiovascular reconstruction.
  • To assess the efficacy and safety of this composite membrane in repairing major vessels and intracardiac defects.

Main Methods:

  • Harvesting of autologous parietal peritoneum and posterior rectus sheath from twelve adult canines.
  • Repair of right ventricular outflow tract and pulmonary artery annuloplasty in six canines.
  • Repair of surgically created secundum atrial septal defects in six canines under cardiopulmonary bypass.

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Main Results:

  • Post-operative autopsy at 90 days showed intact grafts without aneurysms or thrombi.
  • Histological examination confirmed membrane integrity, cellular viability, and endothelialization.
  • Mild intrapericardial adhesions and pericardial reactions were observed.

Conclusions:

  • Autologous peritoneum and rectus sheath demonstrated successful application in repairing vascular and intracardiac defects.
  • This biologic membrane shows promise as a substitute for pericardium in cardiac surgery.
  • Further research is warranted prior to clinical application.