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Thyroid and adrenal function in HIV-infected outpatients

T H Schürmeyer1, V Müller, A von zur Mühlen

  • 1Department Endocrinology and Metabolism, FPP, Trier University, Germany.

European Journal of Medical Research
|May 28, 1997
PubMed
Summary

Thyroid and endocrine function changes, including increased thyroxine-binding globulin (TBG) and decreased dehydroepiandrosterone sulfate (DHEAS), may indicate HIV disease progression. These hormonal shifts correlate with lower CD-4 cell counts in infected men.

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Area of Science:

  • Endocrinology
  • Infectious Diseases
  • HIV/AIDS Research

Background:

  • HIV infection can impact various bodily systems, including endocrine function.
  • Understanding endocrine alterations in HIV is crucial for monitoring disease progression.

Purpose of the Study:

  • To investigate thyroid and endocrine function parameters in HIV-infected men.
  • To identify potential endocrine markers associated with HIV disease progression.

Main Methods:

  • Studied 100 HIV-infected men categorized by CDC criteria.
  • Assessed plasma levels of TBG, CBG, T4, T3, DHEAS, and urinary excretion of aldosterone, cortisol, and catecholamines.
  • Correlated endocrine parameters with CD-4 cell counts and body mass index.

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Main Results:

  • Disease progression showed increased plasma TBG (44%) and CBG (15%), decreased T4/TBG ratio (20%), lower plasma DHEAS (30%), and reduced urinary aldosterone (70%).
  • Plasma T4, T3, TSH, and urinary cortisol/catecholamines remained unaffected.
  • Positive correlations found between CD-4 count and T4/TBG ratio/DHEAS; inverse correlations between TBG and CD-4 count/DHEAS.

Conclusions:

  • Elevated plasma TBG and a shift towards cortisol secretion may serve as endocrine markers for HIV disease progression.
  • Hormonal changes like decreased DHEAS and aldosterone are linked to disease advancement in HIV-infected individuals.