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[Salbutamol intoxication]

H D Danenberg¹

¹Division of Medicine, Hadassah University Hospital, Jerusalem.

|April 15, 1997

Summary

A young asthmatic patient experienced severe symptoms after ingesting high doses of salbutamol (Albuterol) and paracetamol. Prompt medical treatment, including N-acetylcysteine, led to a full recovery within 24 hours.

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Area of Science:

Clinical Toxicology
Pharmacology

Background:

Asthma management often involves salbutamol (Albuterol), a beta-2 agonist.
Paracetamol overdose is a common cause of acute liver injury.

Observation:

A 20-year-old asthmatic woman presented with significant overdose of salbutamol (300 mg) and paracetamol (30 g).
Clinical manifestations included sinus tachycardia (160/min), hypotension (80/50 mmHg), tremor, hypokalemia (2.1 mEq/l), and hyperglycemia (12.1 mEq/l).

Findings:

The patient exhibited a complex toxidrome involving both stimulant-like effects from salbutamol and potential paracetamol toxicity indicators.
Electrolyte and glucose disturbances were noted, requiring specific interventions.

Implications:

This case highlights the critical importance of recognizing and managing co-ingestions of common medications.
Aggressive supportive care and targeted treatments like N-acetylcysteine are crucial for favorable outcomes in overdose scenarios.
Understanding the combined effects of salbutamol and paracetamol overdose is vital for emergency medicine and toxicology specialists.

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