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Analysis of ribosomal and alphoid repetitive DNA by fiber-FISH
C Shiels1, C Coutelle, C Huxley
1Department of Biochemistry and Molecular Genetics, Imperial College School of Medicine at St. Mary's London, UK.
Cytogenetics and Cell Genetics
|January 1, 1997
Abstract:
We have used fluorescence in situ hybridization to extended DNA fibers (fiber-FISH) to analyse the alpha-satellite and rDNA arrays on a human chromosome 22. The rDNA could be seen as a string of signals spanning about 430 kb. The bulk of the alphoid DNA was found in a single large array of about 2.6 Mb.